From the Wikipedia page 
Isère (French pronunciation: [izɛːʁ]; Arpitan: Isera, Occitan: Isèra) is a department in the Auvergne-Rhône-Alpes region in eastern France named after the river Isère.
Isère is one of the original 83 departments created during the French Revolution on March 4, 1790. It was created from part of the former province of Dauphiné. Its area has been reduced twice, in 1852 and again in 1967, on both occasions losing territory to the department of Rhône.
In 1852 in response to rapid urban development round the edge of Lyon, the (hitherto Isère) communes of Bron, Vaulx-en-Velin, Vénissieux and Villeurbanne were transferred to Rhône. In 1967 the redrawing of local government borders led to the creation of the Urban Community of Lyon (more recently known simply as Greater Lyon / Grand Lyon). At that time intercommunal groupings of this nature were not permitted to straddle departmental frontiers, and accordingly 23 more Isère communes (along with 6 communes from Ain) found themselves transferred to Rhône. The affected Isère communes were Chaponnay, Chassieu, Communay, Corbas, Décines-Charpieu, Feyzin, Genas, Jonage, Jons, Marennes, Meyzieu, Mions, Pusignan, Saint-Bonnet-de-Mure, Saint-Laurent-de-Mure, Saint-Pierre-de-Chandieu, Saint-Priest, Saint-Symphorien-d'Ozon, Sérézin-du-Rhône, Simandres, Solaize, Ternay and Toussieu.
Most recently, on 1 April 1971, Colombier-Saugnieu was lost to Rhône. Banners appeared in the commune's three little villages at the time proclaiming "Dauphinois toujours" (Always Dauphinois)
Isère was also the name of the French ship which delivered the 214 boxes holding the Statue of Liberty.